What makes you h*te the most beautiful of the Lannisters?

Apart from arming religi0us fanatics that spiraled out of her control then bl0wing up the Sept of Baelor(thereby unaliving hundreds) as a result, framing Tyrion for Joffrey's demise, cancelling Missandei's life subscription and refusing to evacuate KL, what else makes you dislike the most beautiful of the Lannisters?